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KMID : 0370219970410020187
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Yakhak Hoeji
1997 Volume.41 No. 2 p.187 ~ p.194
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Synthesis and Biological Evaluation of Allylamine Antimycotics
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정병호/Chung BH
조원제/천승훈/박면지/유진철/천문우/Cho WJ/Cheon SH/Park MJ/Yoo JC/Chun MW
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Abstract
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For the development of antifungal agents, modification of naftifine which exhibits significant antimycotic activity was performed by replacing the naphthalene ring of it to hetero cyclic rings such as morpholine. benzothiazole, piperidine and pyridine derivatives. The synthesized compounds were tested in vitro antifungal activity against five different fungi with naftifine as a comparative antimycotic molecule. From the biological evaluation two compounds, (E)-N-(3-phenyl-2-propenyl)-N-(4-piperidinylmethyl)amine(3d) and (E)-N-(3-phenyl-2-propenyl)-N-(3-pyridylmethyl)amine(3f) showed relatively noticeable activity(MIC=50mcg/ml). On the other hand, the other compounds had no activity.
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